Matt Schaub, Texans, had 328 yards and two touchdowns in Houston's 31-24 win over Chicago.
Aaron Rodgers, Packers, threw for 308 yards and three touchdowns in Green Bay's 31-21 win over Detroit.
Joe Flacco, Ravens, finished with 297 yards in Baltimore's 27-7 win over Jacksonville.
Kurt Warner, Cardinals, had 263 yards and four touchdowns in Arizona's 34-21 win over Seattle.
Peyton Manning, Colts, was 7 of 7 for 95 yards with one touchdown and a perfect rating of 158.3 in Indianapolis' 23-0 win over Tennessee, extending his league record of 4,000-yard seasons to nine before leaving after one series.
Michael Turner, Falcons, ran for 208 yards and a touchdown in Atlanta's 31-27 win over St. Louis.
DeAngelo Williams, Panthers, finished with 178 yards in Carolina's win.
Michael Bush, Raiders, had 177 yards and two touchdowns in Oakland's 31-24 win over Tampa Bay.
Steven Jackson, Rams, finished with 161 yards and two touchdowns in St. Louis' loss.
Fred Jackson, Bills, had 136 yards in Buffalo's 13-0 loss to New England.
Andre Johnson, Texans, caught 10 passes for 148 yards and two touchdowns in Houston's victory.
Steve Smith, Panthers, had five catches for 134 yards in Carolina's win.
Larry Fitzgerald, Cardinals, caught five passes for 130 yards and two touchdowns in Arizona's win.
Mark Clayton, Ravens, had four catches for 128 yards in Baltimore's win.
Marques Colston, Saints, had seven catches for 123 yards and a touchdown in a loss.
Terrell Owens, Cowboys, had 6 catches for 103 yards in Dallas' 44- 6 loss to Philadelphia.
John Kasay, Panthers, made four field goals and three extra points in Carolina's victory, including a 42-yarder to win it with 1 second remaining.
David Akers, Eagles, made three goals and five extra points in Philadelphia's win.
John Carney, Giants, made four field goals in New York's 20-19 loss to Minnesota. Ryan Longwell made a game-winning 50-yarder to give the Vikings the victory.
Adam Vinatieri, Colts, made three field goals in Indianapolis' win.
Phillip Merling, Dolphins, returned an interception 29 yards for a touchdown in Miami's 24-17 win over the Jets.
Chris Clemons, Eagles, returned a fumble 73 yards for a touchdown and Joselio Hanson, Eagles, returned a fumble 96 yards for a touchdown in Philadelphia's win.